| BINGE DRINKING CAUSES INSULIN RESISTANCE:CONTRIBUTING FACTOR IN ALZHEIMER'S DISEASE |
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Binge drinking causes insulin resistance, which increases the risk of Type 2 diabetes, according to the results of an animal study led by researchers at the Diabetes Obesity and Metabolism Institute at the Icahn School of Medicine at Mount Sinai. The authors further discovered that alcohol disrupts insulin-receptor signaling by causing inflammation in the hypothalamus area of the brain. Chronic peripheral hyperinsulinemia (as occurs in insulin resistance) downregulates insulin receptors (IR) at BBB, the blood brain barrier, impairing insulin transport into the brain. Decreased brain insulin levels and/or signaling were associated to impaired learning, memory, and age-related neurodegenerative diseases.
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